A new type of surgical glue speeds up recovery and helps numb the wound
Researchers have created a new type of surgical glue that helps connect blood vessels and also helps them heal and relieve pain.
A team of materials scientists from Nanyang University of Technology, together with doctors from the Singapore General Hospital, developed a one-component photoactive adhesive CaproGlu. It consists of a biodegradable polymer polycaprolactone and light-sensitive diazirin molecules, which form strong bonds when activated.
Under the influence of a low dose of ultraviolet light, the glue changes from a liquid to a solid state, but remains flexible thanks to bio-rubber, which dissolves in body tissues in a few weeks. The cured mixture is 3-7 times stronger than other commercial bioadhesives, and is comparable in shear strength to collagen and muscle tissue.
In animal experiments, the team showed that using CaproGlu allows blood vessels to be connected with just four stitches instead of eight. This reduces the operation time by 25%. It has also been found that adding pain relievers and anesthetics to the adhesive helps to efficiently deliver them to the tissues, and reduces the need for drugs during and after surgery..
Recently, Singaporean researchers have also shown that micropores are formed in the folds of the skin when it is compressed, through which the same amount of medicine can penetrate, as through dozens of microneedles..
text: Ilya Bauer, photo: Nanyang Technological University